Adriaan bergh and melinda bam dating simulator

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Publications in peer-reviewed outlets 2005-2016

Bisogna Maria ; A. Berchuck Andrew ; E. P-gp-deficient mice also displayed clearly increased susceptibility to salinomycin toxicity. Thus far, P-gp was thought to affect mainly hydrophobic, positively charged or neutral drugs in vivo. Our data show that P-gp can also be a major determinant of the pharmacokinetic behavior and toxicity of an organic anionic drug. Variation in P-gp activity might thus directly affect the effective exposure to salinomycin and possibly to other anionic drugs and toxin substrates.

Individuals with reduced or absent P-gp activity could therefore be more susceptible to salinomycin toxicity. The purpose of this study was to develop a rapid in vitro method for assessing salinomycin and mone PubMed Central Background The natural polyether ionophorous antibiotics are used for the treatment of coccidiosis in poultry and ruminants. They are effective agents against infections caused by Gram-positive microorganisms.

On the other hand, it was found that some of these compounds selectively bind lead II ions in in vivo experiments, despite so far no Pb II -containing compounds of defined composition have been isolated and characterized. To assess the potential of polyether ionophores as possible antidotes in the agriculture, a detailed study on their in vitro complexation with toxic metal ions is required.